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Integrated Multi-Omics and Pathomics Analysis for Prognostic Modeling of Hepatocellular Carcinoma Reveals Oxidative Stress-Driven Immunometabolic Regulatory Mechanisms

2025-10-31

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC), a major cause of cancer mortality, exhibits strong ties to oxidative stress (OS), though integrated multi-omics studies linking OS mechanisms to clinically predictive models remain scarce. To address this, we integrated European-descent GWAS data (2,852 HCC cases vs. 447,587 controls) with 1,065 OS-related genes, identifying 176 potential HCC-associated g...

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Literature Corpus work
68899c1a-7924-5de1-9275-c9d54678fbfb
DOI
10.21203/rs.3.rs-7489138/v1
Open publication

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Integrated Multi-Omics and Pathomics Analysis for Prognostic Modeling of Hepatocellular Carcinoma Reveals Oxidative Stress-Driven Immunometabolic Regulatory MechanismsDOI 10.21203/rs.3.rs-7489138/v1
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