Electronic DNA Analysis of CSF Cell-free Tumor DNA to Quantify Multi-gene Molecular Response in Pediatric High-grade Glioma.

doi:10.1158/1078-0432.CCR-20-2066

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Article

Electronic DNA Analysis of CSF Cell-free Tumor DNA to Quantify Multi-gene Molecular Response in Pediatric High-grade Glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2020

Bruzek Amy K, Ravi Karthik, Muruganand Ashwath, Wadden Jack, Babila Clarissa May, Cantor Evan, Tunkle Leo, Wierzbicki Kyle, Stallard Stefanie, Dickson Robert P, Wolfe Ian, Mody Rajen, Schwartz Jonathan, Franson Andrea, Robertson Patricia L, Muraszko Karin M, Maher Cormac O, Garton Hugh J L, Qin Tingtin, Koschmann Carl

Abstract excerpt

PURPOSE: Pediatric high-grade glioma (pHGG) diagnosis portends poor prognosis and therapeutic monitoring remains difficult. Tumors release cell-free tumor DNA (cf-tDNA) into cerebrospinal fluid (CSF), allowing for potential detection of tumor-associated mutations by CSF sampling. We hypothesized that direct, electronic analysis of cf-tDNA with a handheld platform (Oxford Nanopore MinION) could quantify...

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Identifiers

PMID: 33087334
DOI: 10.1158/1078-0432.CCR-20-2066
PMCID: PMC7710567

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