Article
Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke.
PloS one - 3 Feb 2010
Cervera Alvaro, Planas Anna M, Justicia Carles, Urra Xabier, Jensenius Jens C, Torres Ferran, Lozano Francisco, Chamorro Angel
Abstract excerpt
BACKGROUND: The complement system is a major effector of innate immunity that has been involved in stroke brain damage. Complement activation occurs through the classical, alternative and lectin pathways. The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs). Here we investigated whether the lectin pathway contributes to stroke outcome in mice and humans....
Topics
- Aged
- Aged, 80 and over
- Animals
- Blotting, Western
- Brain Ischemia
- Cell Line
- Complement C3
- Female
- Genotype
- Humans
- Immunohistochemistry