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Article

Pharmacogenotyping of CYP3A5 in predicting dose-adjusted trough levels of tacrolimus among Malaysian kidney-transplant patients.

Canadian journal of physiology and pharmacology - 1 Jan 2014

Hamzah Sharina, Teh Lay Kek, Siew John Shia Kwong, Ahmad Ghazali, Wong Hin Seng, Zakaria Zainul Amiruddin, Salleh Mohd Zaki

Abstract excerpt

Tacrolimus (FK506) is a calcineurin inhibitor with a narrow therapeutic index that exhibits large interindividual variation. Seventy-eight kidney transplant patients treated with tacrolimus were recruited to study the correlation of dose adjusted trough level (level/dose; L/D) of tacrolimus with CYP3A5 and ABCB1 genotypes, as well as the mRNA copy number of ABCB1 in blood. Patients were genotyped for ABCB1...

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Identifiers

PMID: 24383873
DOI: 10.1139/cjpp-2013-0128

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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