Article

Ciliary and non-ciliary functions of CEP104 in Xenopus

2025-06-15

Abstract excerpt

Cep104 is a conserved protein essential for centriole and cilia function, with mutations linked to Joubert Syndrome. We investigated its role in Xenopus embryonic development, revealing that Cep104 is crucial for neural tube closure (NTC) through regulating apical constriction. We show that the role of Cep104 in cilia and hedgehog signalling cannot alone explain the elicited defects. We go on to show that Cep104 l...

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Literature Corpus work: 11f28ea9-ce19-5fcf-bd4c-77204d9d3bd5
DOI: 10.1101/2025.06.12.659327

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