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Article

Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.

The Journal of biological chemistry - 23 Oct 2020

Yamazoe Takashi, Nagai Tomoaki, Umeda Shinya, Sugaya Yuko, Mizuno Kensaku

Abstract excerpt

Primary cilia are generated through the extension of the microtubule-based axoneme. Centrosomal protein 104 (CEP104) localizes to the tip of the elongating axoneme, and CEP104 mutations are linked to a ciliopathy, Joubert syndrome. Thus, CEP104 has been implicated in ciliogenesis. However, the mechanism by which CEP104 regulates ciliogenesis remains elusive. We report here that CEP104 is critical for cilium...

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Identifiers

PMID: 32820051
DOI: 10.1074/jbc.RA120.013334
PMCID: PMC7586207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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