Article

Study on gene knockout mice and human mutant individual reveals absence of CEP78 causes photoreceptor and sperm flagella impairments

2022-01-26

Abstract excerpt

<h4>Background</h4> Cone-rod dystrophy (CRD) is a genetically inherited retinal disease characterized by photoreceptor degeneration. In some rare cases, CRD and hearing loss can be associated with male fertility, while the underlying mechanism is not well known. <h4>Methods</h4> Using CRISPR/Cas9 system, we generated Cep78 -/- mice. And electroretinogram (ERG), immunofluorescence staining and transmission elec...

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Literature Corpus work: 8d2bad61-033d-50aa-9527-019b04f30773
DOI: 10.1101/2022.01.25.477668

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