Article

HIV-1 mRNA Knockdown with CRISPR/Cas9 Enhances Neurocognitive Function

2023-10-16

Abstract excerpt

<title>Abstract</title> <p>Mixed glia are infiltrated with HIV-1 virus early in the course of infection leading to the development of a persistent viral reservoir in the central nervous system. Modification of the HIV-1 genome using gene editing techniques, including CRISPR/Cas9, has shown great promise towards eliminating HIV-1 viral reservoirs; whether these techniques are capable of removing HIV-1 viral protei...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11f182c0-e505-5339-8144-beb8a46105b6
DOI: 10.21203/rs.3.rs-3266933/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HIV-1 mRNA Knockdown with CRISPR/Cas9 Enhances Neurocognitive FunctionDOI 10.21203/rs.3.rs-3266933/v1Read

CRISPR/CAS as a Powerful Tool for Human Immunodeficiency Virus Cure: A ReviewSemantic proximity Read

A CRISPR/Cas9 guidance RNA screen platform for HIV provirus disruption and HIV/AIDS gene therapy in astrocytesSemantic proximity Read

Transcriptional Mapping of Neuro-Immune Interactions during Homeostasis and HIV infection using Microglia-containing Human Cerebral AssembloidsSemantic proximity Read

Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular DamageSemantic proximity Read

Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoidsSemantic proximity Read

Adult human brain tissue cultures to study neuroHIVSemantic proximity Read

A novel glia-immune humanized mouse model for investigating neuroimmune mechanisms in CNS HIV infection and diverse neurological disordersSemantic proximity Read

Investigation of CNS damage following HIV infection and methamphetamine exposure using human iPSC-derived microglia and 3D cerebral assembloid modelsSemantic proximity Read

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized MiceSemantic proximity Read

Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteinsSemantic proximity Read

CRISPR based editing of SIV proviral DNA in ART treated non-human primatesSemantic proximity Read

The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) Recruits CoREST Transcription Repressor Complexes to Silence HIV Following Proviral Reactivation in Microglial CellsSemantic proximity Read