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Article

CRISPR based editing of SIV proviral DNA in ART treated non-human primates

27 Nov 2020

Abstract excerpt

Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non-human primate model of HIV infection, with adeno-associated virus 9 (AAV9)-CRISPR/Cas9 gene editing construct designed for eliminating proviral SIV DNA, leads to broad distribution of editing molecules and precise cleavage and removal of...

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PMID: 33247091
DOI: 10.1038/s41467-020-19821-7

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