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The Mutated p.H222P A-type Lamins Drive Loxl2-Mediated Extracellular Matrix Remodeling in Both Patient-Derived Cardiomyocytes and Mouse Models of Dilated Cardiomyopathy

2025-01-14

Abstract excerpt

<h4>ABSTRACT</h4> LMNA cardiomyopathy, caused by mutations in the LMNA gene, is a severe form of dilated cardiomyopathy characterized by arrhythmias, contractile dysfunction, and increased myocardial fibrosis, which impairs left ventricular function and predisposes to heart failure. While the disease has been well characterized, a lack of insight into the pathogenesis impeded the development of therapies. We her...

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Literature Corpus work
83ef4a8f-e510-5fd7-9842-d000273241bf
DOI
10.1101/2025.01.10.632312
Open publication

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