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Article

Non-genetic adaptive resistance to KRASG12C inhibition: EMT is not the only culprit

22 Nov 2022

Abstract excerpt

Adaptions to therapeutic pressures exerted on cancer cells enable malignant progression of the tumor, culminating in escape from programmed cell death and development of resistant diseases. A common form of cancer adaptation is non-genetic alterations that exploit mechanisms already present in cancer cells and do not require genetic modifications that can also lead to resistance mechanisms....

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PMID: 36483040
DOI: 10.3389/fonc.2022.1004669

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