Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of the R823W mutation on the interaction of the ANKS6-ANKS3: insights from molecular dynamics simulation and free energy analysis.

Journal of biomolecular structure & dynamics - 1 May 2016

Kan Wei, Fang Fengqin, Chen Lin, Wang Ruige, Deng Qigang

Abstract excerpt

The sterile alpha motif (SAM) domain of the protein ANKS6, a protein-protein interaction domain, is responsible for autosomal dominant polycystic kidney disease. Although the disease is the result of the R823W point mutation in the SAM domain of the protein ANKS6, the molecular details are still unclear. We applied molecular dynamics simulations, the principal component analysis, and the molecular mechanics...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Hydrogen Bonding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Nuclear Proteins

Share to Protein Conformation

Share to Protein Interaction Domains and Motifs

Source

Identifiers

PMID: 26295479
DOI: 10.1080/07391102.2015.1071281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of the R823W mutation on the interaction of the ANKS6-ANKS3: insights from molecular dynamics simulation and free energy analysis.PMID 26295479Read ↗

Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3.Semantic proximity Read ↗

A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation.Semantic proximity Read ↗

Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction.Semantic proximity Read ↗

A novel approach to study multi-domain motions in JAK1's activation mechanism based on energy landscape.Semantic proximity Read ↗

Structural modeling of human AKAP3 protein and in silico analysis of single nucleotide polymorphisms associated with sperm motility.Semantic proximity Read ↗

Exploring conformation changes of Janus kinase 2 pseudokinase mediated by mutations through Gaussian accelerated molecular dynamics and principal component analysis.Semantic proximity Read ↗

Deciphering the effect of mutations in MMAA protein causing methylmalonic acidemia-A computational approach.Semantic proximity Read ↗

Exploring the mechanism of a regulatory SNP of KLK3 by molecular dynamics simulation.Semantic proximity Read ↗

The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes.Semantic proximity Read ↗

Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein-protein interactions.Semantic proximity Read ↗

Elucidating the functional impact of G137V and G144R variants in Maroteaux Lamy's Syndrome by Molecular Dynamics Simulation.Semantic proximity Read ↗

Uncovering allostery and regulation in SAMHD1 through molecular dynamics simulations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.