Article

Improving Differential Expression and Survival Analyses with Sample Specific Compartment Deconvolution

2025-06-07

Abstract excerpt

<h4>Motivation</h4> Studies on bulk RNA-seq of tumor biopsies can yield incorrect results because varying proportions of non-tumor tissues in the samples obscure the true signal and impact the accuracy of survival and differential expression analyses. Single-cell sequencing avoids these problems, but is still too expensive in clinical settings. Other deconvolution algorithms extract tissue-specific gene expressio...

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Literature Corpus work: deb13cfe-12cb-546a-a3f1-ffb7cf68d688
DOI: 10.1101/2025.06.04.657908

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