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Article

Multimodal-based analysis of single-cell ATAC-seq data enables highly accurate delineation of clinically relevant tumor cell subpopulations.

Genome medicine - 13 Jan 2026

Xiong Kewei, Wang Wei, Ding Ruofan, Luo Dinglin, Qin Yangmei, Zou Xudong, Wang Jiguang, Yu Chen, Li Lei

Abstract excerpt

BACKGROUND: Accurately identifying functionally distinct tumor cell subpopulations remains a critical challenge in cancer research. While single-cell epigenomics assays provide powerful insights into tumor heterogeneity beyond gene expression, computational limitations have hindered their application. METHODS: We introduce Multimodal-based Analysis of scATAC-Seq data (MAAS), a method that integrates chromatin...

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Identifiers

PMID: 41530870
DOI: 10.1186/s13073-026-01599-w
PMCID: PMC12888741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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