Article

Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancer

2020-10-02

Abstract excerpt

Cancers can vary greatly in their transcriptomes. In contrast to alterations in specific genes or pathways, differences in tumor cell total mRNA content have not been comprehensively assessed. Technical and analytical challenges have impeded examination of total mRNA expression at scale across cancers. To address this, we developed a model for quantifying tumor-specific total mRNA expression (TmS) from bulk sequen...

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Literature Corpus work: 076168f0-ecaa-5f90-926a-c6dd8809e32b
DOI: 10.1101/2020.09.30.306795

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