Article

KINOMO: A non-negative matrix factorization framework for recovering intra- and inter-tumoral heterogeneity from single-cell RNA-seq data

2022-05-04

Abstract excerpt

Single-cell RNA-sequencing (scRNA-seq) is a powerful technology to uncover cellular heterogeneity in tumor ecosystems. Due to differences in underlying gene load, direct comparison between patient samples is challenging, and this is further complicated by the sparsity of data matrices in scRNA-seq. Here, we present a factorization method called KINOMO ( K ernel d I fferentiability correlation-based NO n-negativ...

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Literature Corpus work: 7c38ba55-3421-5334-85c6-37aede1007ad
DOI: 10.1101/2022.05.02.490362

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