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Article

Rewiring miR-22/SNAI1 via CRISPR-based edge editing destabilizes the epithelial phenotype.

NPJ systems biology and applications - 29 Apr 2026

Nguyen John T, Huang Lijia, Levine Herbert, Lu Mingyang, Bleris Leonidas

Abstract excerpt

Epithelial-to-Mesenchymal Transition (EMT) is a critical biological process by which cells acquire enhanced migratory and invasive properties. A key signaling pathway involved in EMT phenotypes includes transforming growth factor β (TGFβ) and transcription factors (TFs) such as SNAIL, ZEB, and TWIST. Additionally, microRNAs (miRNAs) - small, non-coding molecules that regulate gene expression by targeting mRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42049733
DOI: 10.1038/s41540-026-00720-4
PMCID: PMC13333950

Genes

SNAI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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