Article

Applications of adeno-associated virus for 3D single-cell morphometric analysis in iPSC-derived midbrain organoids

2026-05-16

Abstract excerpt

Human midbrain organoids (hMBOs) are emerging in vitro models to mirror the cellular diversity and the structural complexity of the developing human brain. However, the dense neural network, limits the investigation of individual cells’ morphology or cell-cell connectivity, which is mostly restricted to fixed organoids following extensive optical clearing techniques. To better resolve individual cells within a br...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb480526-9d9d-5222-8d19-6ae532dc5711
DOI: 10.64898/2026.05.14.725219

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Applications of adeno-associated virus for 3D single-cell morphometric analysis in iPSC-derived midbrain organoidsDOI 10.64898/2026.05.14.725219Read

Mass Generation, Neuron Labelling and 3D Imaging of MinibrainsSemantic proximity Read

Validation of non-destructive morphology-based selection of cerebral cortical organoids by paired morphological and single-cell RNA-seq analysesSemantic proximity Read

Multiscale 3D phenotyping of human cerebral organoids.Semantic proximity Read

Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoidsSemantic proximity Read

Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar developmentSemantic proximity Read

Morphodynamics of human early brain organoid developmentSemantic proximity Read

Modeling neurological disorders using brain organoids.Semantic proximity Read

Reconstruction of the human nigrostriatal pathway in vitro reveals target-dependent dopamine neuron maturationSemantic proximity Read

Interregional human assembloids recapitulate fetal brain morphologies and enhance neuronal complexitySemantic proximity Read

ML-guided robotic microinjection of single neurons in human brain organoidsSemantic proximity Read

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoidsSemantic proximity Read

Human assembloidsSemantic proximity Read