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Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated Virus

11 Oct 2022

Abstract excerpt

Cortical organoids are 3D structures derived either from human embryonic stem cells or human induced pluripotent stem cells with their use exploding in recent years due to their ability to better recapitulate the human brain in vivo in respect to organization; differentiation; and polarity. Adeno-associated viruses (AAVs) have emerged in recent years as the vectors of choice for CNS-targeted gene therapy. Here;...

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PMID: 36291062
DOI: 10.3390/cells11203194

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