Article

Pleiotropic Mapping and Annotation Selection in Genome-wide Association Studies with Penalized Gaussian Mixture Models

2018-01-31

Abstract excerpt

<h4>Motivation</h4> Genome-wide association studies (GWASs) have identified many genetic loci associated with complex traits. A substantial fraction of these identified loci are associated with multiple traits – a phenomena known as pleiotropy. Identification of pleiotropic associations can help characterize the genetic relationship among complex traits and can facilitate our understanding of disease etiology. Ef...

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Literature Corpus work: 1152355f-d3b4-5836-a2a5-e5a679ea058a
DOI: 10.1101/256461

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