Article

Transcriptome-Wide Root Causal Inference

2024-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Root causal genes correspond to the first gene expression levels perturbed during pathogenesis by genetic or non-genetic factors. Targeting root causal genes has the potential to alleviate disease entirely by eliminating pathology near its onset. No existing algorithm discovers root causal genes from observational data alone. We therefore propose the Transcriptome-Wide Root Causal Inference (TWRC...

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Literature Corpus work: 113ee89d-d6c8-5f29-81d8-b1604cbdbda0
DOI: 10.1101/2024.07.22.24310837

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