Article

Discovering Root Causal Genes with High Throughput Perturbations

2024-01-14

Abstract excerpt

Root causal gene expression levels – or root causal genes for short – correspond to the initial changes to gene expression that generate patient symptoms as a downstream effect. Identifying root causal genes is critical towards developing treatments that modify disease near its onset, but no existing algorithms attempt to identify root causal genes from data. RNA-sequencing (RNA-seq) data introduces challenges su...

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Literature Corpus work: 6dca88c0-97a4-53fc-9cfb-d56ce9ec8c01
DOI: 10.1101/2024.01.13.574491

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