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Article

Causal inference of gene regulation with subnetwork assembly from genetical genomics data.

Nucleic acids research - 1 Mar 2014

Peng Chien-Hua, Jiang Yi-Zhi, Tai An-Shun, Liu Chun-Bin, Peng Shih-Chi, Liao Chun-Ta, Yen Tzu-Chen, Hsieh Wen-Ping

Abstract excerpt

Deciphering the causal networks of gene interactions is critical for identifying disease pathways and disease-causing genes. We introduce a method to reconstruct causal networks based on exploring phenotype-specific modules in the human interactome and including the expression quantitative trait loci (eQTLs) that underlie the joint expression variation of each module. Closely associated eQTLs help anchor the...

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Identifiers

PMID: 24322297
DOI: 10.1093/nar/gkt1277
PMCID: PMC3950678

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RXRB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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