Article

Polymorphisms in STING affect human innate immune responses to poxviruses

2020-05-31

Abstract excerpt

We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of > 1,600 subjects. We identified a cluster of SNPs on chromosome 5 (5q31.2) that were significantly associated (p-value: 1.3 × 10 −12 – 1.5×10 −36 ) with IFNα response to in vitro poxvirus stimulation. Examination of these SNPs led to the functional testing of rs1131769, a non...

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Literature Corpus work: 1137de74-8b8c-54c0-950e-035bebecaa85
DOI: 10.1101/2020.05.28.121657

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