Article
Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses.
Frontiers in immunology - 1 Jan 2020
Kennedy Richard B, Haralambieva Iana H, Ovsyannikova Inna G, Voigt Emily A, Larrabee Beth R, Schaid Daniel J, Zimmermann Michael T, Oberg Ann L, Poland Gregory A
Abstract excerpt
We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of 1,653 subjects. We did not observe any polymorphisms associated with standard vaccine response outcomes (e.g., neutralizing antibody, T cell ELISPOT response, or T cell cytokine production); however, we did identify a cluster of SNPs on chromosome 5 (5q31.2) that were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.