Article

A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses

2021-07-17

Abstract excerpt

<h4>Summary</h4> The induction of interferon-stimulated genes by signal transducer and activator of transcription (STAT) proteins, is a critical host defence to fight virus infections. Here, a highly expressed poxvirus protein 018 is shown to inhibit IFN-induced signalling by binding the SH2 domain of STAT1 to prevent STAT1 association with an activated IFN receptor. Despite the presence of additional inhibitors...

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Identifiers and source

Literature Corpus work: 90c35c4b-b768-5b52-b6df-d20e4e6a6985
DOI: 10.1101/2021.07.17.452491

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