Article
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Human genetics - 1 Sept 2012
Kennedy Richard B, Ovsyannikova Inna G, Pankratz V Shane, Haralambieva Iana H, Vierkant Robert A, Poland Gregory A
Abstract excerpt
The role that genetics play in response to infection or disease is becoming increasingly clear as we learn more about immunogenetics and host-pathogen interactions. Here we report a genome-wide analysis of the effects of host genetic variation on cytokine responses to vaccinia virus stimulation in smallpox vaccine recipients. Our data show that vaccinia stimulation of immune individuals results in secretion of...
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