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Reduced Cdc14 phosphatase activity impairs septation, hyphal differentiation and pathogenesis and causes echinocandin hypersensitivity in <i>Candida albicans</i>

2022-09-30

Abstract excerpt

<h4>ABSTRACT</h4> The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae, Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit. However, this essential function is not broadly conserved and requires a small fraction of normal Cdc14 activity. It remains unclear what fungal Cdc14 functions require high Cdc14 activity. We identified an invariant...

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Literature Corpus work
111a760f-2f6a-5d86-a9c2-a8661857aa1b
DOI
10.1101/2022.09.29.510203
Open publication

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