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Article

Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans.

Molecular and cellular biology - 1 Dec 2000

Chen J, Zhou S, Wang Q, Chen X, Pan T, Liu H

Abstract excerpt

Both mitogen-activated protein kinases and cyclin-dependent kinases play a role in hyphal development in Candida albicans. Using an oligonucleotide probe-based screen, we have isolated a new member of the Cdc2 kinase subfamily, designated Crk1 (Cdc2-related kinase). The protein sequence of Crk1 is most similar to those of Saccharomyces cerevisiae Sgv1 and human Pkl1/Cdk9. In S. cerevisiae, CRK1 suppresses some,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11073971
DOI: 10.1128/MCB.20.23.8696-8708.2000
PMCID: PMC86484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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