Article
CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle.
Nature - 1 Nov 2019
Sarek Grzegorz, Kotsantis Panagiotis, Ruis Phil, Van Ly David, Margalef Pol, Borel Valerie, Zheng Xiao-Feng, Flynn Helen R, Snijders Ambrosius P, Chowdhury Dipanjan, Cesare Anthony J, Boulton Simon J
Abstract excerpt
The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3' single-stranded telomere end can assemble into a lasso-like t-loop configuration1,2, which has been proposed to safeguard chromosome ends from being recognized as DNA double-strand breaks2. Mechanisms must also exist to transiently disassemble t-loops to...
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