Chromosome end protection by RAP1-mediated inhibition of DNA-PK

Abstract excerpt

Abstract During classical non-homologous end joining (cNHEJ), DNA-dependent protein kinase (DNA-PK) encapsulates free DNA ends, forming a recruitment platform for downstream end-joining factors including ligase 4 (LIG4) 1 . DNA-PK can also bind telomeres and regulate their resection 2–4 , but does not initiate cNHEJ at this position. How the end-joining process is regulated in this context-specific manner is...

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