TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.

doi:10.1016/j.molcel.2015.12.009

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Article

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.

Molecular cell - 21 Jan 2016

Benarroch-Popivker Delphine, Pisano Sabrina, Mendez-Bermudez Aaron, Lototska Liudmyla, Kaur Parminder, Bauwens Serge, Djerbi Nadir, Latrick Chrysa M, Fraisier Vincent, Pei Bei, Gay Alexandre, Jaune Emilie, Foucher Kevin, Cherfils-Vicini Julien, Aeby Eric, Miron Simona, Londoño-Vallejo Arturo, Ye Jing, Le Du Marie-Hélène, Wang Hong, Gilson Eric, Giraud-Panis Marie-Josèphe

Abstract excerpt

The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps ∼ 90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain. The expression of a wrapping-deficient TRF2 mutant, named Top-less, alters telomeric DNA topology, decreases the number of...

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Identifiers

PMID: 26774283
DOI: 10.1016/j.molcel.2015.12.009
PMCID: PMC5001171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.PMID 26774283Read ↗

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Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the TelomereSemantic proximity Read ↗

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusionsSemantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

Human Rap1 modulates TRF2 attraction to telomeric DNASemantic proximity Read ↗

ZNF524 directly interacts with telomeric DNA and supports telomere integritySemantic proximity Read ↗

Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damageSemantic proximity Read ↗

Homologous recombination generates T-loop-sized deletions at human telomeres.Semantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

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