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NOTCH, WNT, and TGFβ: Key pathways in extravillous trophoblast formation and differentiation

1 Jul 2025

Abstract excerpt

During gestation, the human placenta ensures nutrition, gas exchange, and protection against pathogens for the growing fetus. As key component in placentation, extravillous trophoblasts (EVTs) arise from trophoblast (TB) progenitors through extensive proliferation at placental tip structures. A stepwise and tightly orchestrated differentiation process enables post-proliferative EVTs to invade maternal uterine...

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PMID: 40713400
DOI: 10.1016/j.placenta.2025.07.082

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