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Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy

17 Jan 2024

Abstract excerpt

In humans, balanced invasion of trophoblast cells into the uterine mucosa, the decidua, is critical for successful pregnancy. Evidence suggests that this process is regulated by uterine natural killer (uNK) cells, but how they influence reproductive outcomes is unclear. Here, we used our trophoblast organoids and primary tissue samples to determine how uNK cells affect placentation. By locating potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38237587
DOI: 10.1016/j.stem.2023.12.013

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