Article

Longitudinal analyses reveal age-specific immune correlates of COVID-19 severity

2021-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Severe COVID-19 disproportionately impacts older individuals and those with comorbidities. It is estimated that approximately 80% of COVID-19 deaths are observed among individuals >65 years of age. However, the immunological underpinnings of severe COVID-19 in the aged have yet to be defined. This study captures the longitudinal immune response to SARS-CoV-2 infection in a cohort of young and age...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10d95a51-31f7-5f5e-84e7-9ee9d0fcb4bb
DOI: 10.1101/2021.01.25.21250189

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Longitudinal analyses reveal age-specific immune correlates of COVID-19 severityDOI 10.1101/2021.01.25.21250189Read

Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patientsSemantic proximity Read

Enhanced immune ageing associated with increasing COVID-19 disease severitySemantic proximity Read

Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 ImmunopathologySemantic proximity Read

Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathologySemantic proximity Read

A human circulating immune cell landscape in aging and COVID-19Semantic proximity Read

Molecular and cellular immune features of aged patients with severe COVID-19 pneumoniaSemantic proximity Read

Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistenceSemantic proximity Read

Identifying Age-Related Risk Factors in COVID-19 Independent of Disease SeveritySemantic proximity Read

T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adultsSemantic proximity Read

Aging-related cell type-specific pathophysiologic immune responses that exacerbate disease severity in aged COVID-19 patientsSemantic proximity Read

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19Semantic proximity Read

Age, host response, and mortality in COVID-19Semantic proximity Read