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T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults

2022-12-22

Abstract excerpt

In children and younger adults up to 39 years of age, SARS-CoV-2 usually elicits mild symptoms that resemble the common cold. Disease severity increases with age starting at 30 and reaches astounding mortality rates that are ~330 fold higher in persons above 85 years of age compared to those 18-39 years old. To understand age-specific immune pathobiology of COVID-19 we have analyzed soluble mediators, cellular phe...

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Identifiers and source

Literature Corpus work
0fa9786e-ae5c-5168-82cb-c41c2fd78a2d
DOI
10.1101/2022.12.21.521463
Open publication

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T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adultsDOI 10.1101/2022.12.21.521463
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