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Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology

17 Apr 2024

Abstract excerpt

Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated the impact of aging on host immune response in the blood and the upper airway, as well as the nasal microbiome in a prospective, multicenter cohort of 1031 vaccine-naïve patients hospitalized for COVID-19 between 18 and 96 years...

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PMID: 38630846
DOI: 10.1126/scitranslmed.adj5154

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