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Article

A comprehensive overview of the molecular features and therapeutic targets in BRAFV600E-mutant colorectal cancer.

Clinical and translational medicine - 1 Jul 2024

Gu Ruiqi, Fang Hongsheng, Wang Renjie, Dai Weixing, Cai Guoxiang

Abstract excerpt

As one of the most prevalent digestive system tumours, colorectal cancer (CRC) poses a significant threat to global human health. With the emergence of immunotherapy and target therapy, the prognosis for the majority of CRC patients has notably improved. However, the subset of patients with BRAF exon 15 p.V600E mutation (BRAFV600E) has not experienced remarkable benefits from these therapeutic advancements....

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Source

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Identifiers

PMID: 39073010
DOI: 10.1002/ctm2.1764
PMCID: PMC11283586

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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