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Article

GDF15 promotes 5-Fluorouracil and Oxaliplatin resistance by promoting stem cell-like phenotype in colorectal cancer.

British journal of cancer - 1 Aug 2026

Hashimoto Masahiro, Urabe Shoichiro, Hata Tsuyoshi, Chinen Yoshinao, Haruna Kengo, Takeda Mitsunobu, Sekido Yuki, Hamabe Atsushi, Ogino Takayuki, Miyoshi Norikatsu, Tobo Taro, Mimori Koshi, Uemura Mamoru, Eguchi Hidetoshi, Doki Yuichiro

Abstract excerpt

BACKGROUND: Despite recent advances in chemotherapy for colorectal cancer (CRC), chemotherapy-sensitive tumours often develop resistance to treatment, which remains a major clinical challenge. This acquired chemoresistance limits the efficacy of subsequent therapies and is associated with a poor prognosis. Therefore, this study identified the mechanisms of acquired chemoresistance in CRC and developed innovative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 42120524
DOI: 10.1038/s41416-026-03379-0
PMCID: PMC13427734

Genes

GDF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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