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Article

miR-15a-5p enhances the malignant phenotypes of colorectal cancer cells through the STAT3/TWIST1 and PTEN/AKT signaling pathways by targeting SIRT4.

Cellular signalling - 1 Jan 2023

Deng Jiaqiang, Wang Huani, Liang Yutong, Zhao Lili, Li Yan, Yan Yan, Zhao Hong, Zhang Xiao, Zou Fangdong

Abstract excerpt

Colorectal cancer (CRC) continues to represent one of the major causes of cancer-related mortality and morbidity. MicroRNAs (miRNAs) are confirmed to be involved in modulating substential biological processes by affecting the expression of targeted genes, including carcinogenesis. In the present study, the expression pattern and functional roles of microRNA-15a-5p (miR-15a-5p) in CRC cells were investigated. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

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Source

Identifiers

PMID: 36332797
DOI: 10.1016/j.cellsig.2022.110517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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