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Genetic alteration of ferredoxin NADP <sup>+</sup> -reductase or cysteine desulfurase in piperaquine-resistant <i>Plasmodium berghei</i> restores susceptibility to lumefantrine and abolishes the impact of probenecid, verapamil, and cyproheptadine

2019-11-06

Abstract excerpt

Chemotherapy remains central in the control of malaria; however, resistance has consistently thwarted these efforts. Currently, lumefantrine (LM), and piperaquine (PQ) drugs, are essential components in the mainstay artemisinin-based therapies used for the treatment of malaria globally. Using LM and PQ-resistant Plasmodium berghei , we measured the effect of known chemosensitizers: probenecid, verapamil, or cypro...

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Literature Corpus work
10c2a8ff-4202-5587-8c6c-8fc165c89c24
DOI
10.1101/833145
Open publication

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Genetic alteration of ferredoxin NADP <sup>+</sup> -reductase or cysteine desulfurase in piperaquine-resistant <i>Plasmodium berghei</i> restores susceptibility to lumefantrine and abolishes the impact of probenecid, verapamil, and cyproheptadineDOI 10.1101/833145
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