Article
A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine.
mBio - 9 May 2017
Dhingra Satish K, Redhi Devasha, Combrinck Jill M, Yeo Tomas, Okombo John, Henrich Philipp P, Cowell Annie N, Gupta Purva, Stegman Matthew L, Hoke Jonathan M, Cooper Roland A, Winzeler Elizabeth, Mok Sachel, Egan Timothy J, Fidock David A
Abstract excerpt
Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum resistance to artemisinin-based combination therapies, which includes increasing rates of clinical failure with dihydroartemisinin plus piperaquine (PPQ) in Cambodia. Using zinc finger nuclease-based gene editing, we report that addition of the C101F mutation to the chloroquine (CQ)...
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