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Article

Antifolate-resistant mutants of <i>Plasmodium falciparum</i> dihydrofolate reductase

18 Feb 1997

Abstract excerpt

Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have been linked to antifolate resistance in malaria. We prepared and characterized all seven of the pfDHFR mutants found in nature, as well as six mutants not observed in nature. Mutations involving residues 51, 59, 108, or 164 conferred cross resistance to both the antifolates...

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PMID: 9037017
DOI: 10.1073/pnas.94.4.1124

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