Article

Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications

2025-08-23

Abstract excerpt

Systemic lupus erythematosus (SLE) and melanoma both involve dysregulated immune pathways, yet their molecular convergence remains poorly understood. We performed a cross-disease transcriptomic analysis of melanoma (GSE168204) and SLE (GSE211700) datasets to identify shared signatures of immune activation and immune checkpoint blockade (ICB) response. Differential expression analysis revealed two distinct signatur...

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Literature Corpus work: 10c2463e-f0af-502b-bd84-8fde6549fb24
DOI: 10.1101/2025.08.19.671053

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