Article
Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis.
Aging - 18 Jan 2020
Pan Hui, Lu Linna, Cui Junqi, Yang Yuan, Wang Zhaoyang, Fan Xianqun
Abstract excerpt
Uveal melanoma is an aggressive intraocular malignancy that often exhibits low immunogenicity. Metastatic uveal melanoma samples frequently exhibit monosomy 3 or BAP1 deficiency. In this study, we used bioinformatic methods to investigate the immune infiltration of uveal melanoma samples in public datasets. We first performed Gene Set Enrichment/Variation Analyses to detect immunological pathways that are altered...
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