Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential Treatments Based on Drug-induced Gene Expression Signatures and Longitudinal Systemic Lupus Erythematosus Stratification

29 Oct 2019

Abstract excerpt

Systemic lupus erythematosus (SLE) is a heterogeneous disease with unpredictable patterns of activity. Patients with similar activity levels may have different prognosis and molecular abnormalities. In this study, we aimed to measure the main differences in drug-induced gene expression signatures across SLE patients and to evaluate the potential for clinical data to build a machine learning classifier able to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis and Cardiovascular Diseases
Share to Cytokine Signaling Pathways and Interactions
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31664045
DOI: 10.1038/s41598-019-51616-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential Treatments Based on Drug-induced Gene Expression Signatures and Longitudinal Systemic Lupus Erythematosus StratificationPMID 31664045Read ↗

Deep stratification by transcriptome molecular characters for precision treatment of patients with systemic lupus erythematosusSemantic proximity Read ↗

Stratification of Systemic Lupus Erythematosus Patients with Gene Expression Data Reveals Expression of Distinct Immune PathwaysSemantic proximity Read ↗

Machine learning applied to whole-blood RNA-sequencing data uncovers distinct subsets of patients with systemic lupus erythematosusSemantic proximity Read ↗

Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategySemantic proximity Read ↗

Machine learning applied to whole‐blood RNA‐sequencing data uncovers distinct subsets of patients with systemic lupus erythematosusSemantic proximity Read ↗

Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosusSemantic proximity Read ↗

Adults with systemic lupus exhibit distinct molecular phenotypes in a cross-sectional studySemantic proximity Read ↗

Molecular basis for the disease-modifying effects of belimumab in systemic lupus erythematosus and molecular predictors of early response: blood transcriptome analysis implicates the innate immunity and DNA damage response pathwaysSemantic proximity Read ↗

Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severitySemantic proximity Read ↗

Unsupervised clustering of clinical and laboratory features of systemic lupus erythematosus: insights from a multicentre cohort.Semantic proximity Read ↗

Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease statesSemantic proximity Read ↗

Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.