Article

Mechanism of nucleic-acid-driven LLPS of TDP-43 PLD

2022-11-02

Abstract excerpt

<h4>ABSTRACT</h4> Most membrane-less organelles (MLOs) formed by LLPS contain both nucleic acids and IDR-rich proteins. Currently while IDRs are well-recognized to drive LLPS, nucleic acids are thought to exert non-specific electrostatic/salt effects. TDP-43 functions by binding RNA/ssDNA and its LLPS was characterized without nucleic acids to be driven mainly by PLD-oligomerization, which may further transit int...

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Literature Corpus work: e33533ab-35ca-5e13-8067-d4a82d9626b4
DOI: 10.1101/2022.11.01.514785

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