Article
Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers.
Science (New York, N.Y.) - 6 Sept 2024
Sundaram Laksshman, Kumar Arvind, Zatzman Matthew, Salcedo Adriana, Ravindra Neal, Shams Shadi, Louie Bryan H, Bagdatli S Tansu, Myers Matthew A, Sarmashghi Shahab, Choi Hyo Young, Choi Won-Young, Yost Kathryn E, Zhao Yanding, Granja Jeffrey M, Hinoue Toshinori, Hayes D Neil, Cherniack Andrew, Felau Ina, Choudhry Hani, Zenklusen Jean C, Farh Kyle Kai-How, McPherson Andrew, Curtis Christina, Laird Peter W, Demchok John A, Yang Liming, Tarnuzzer Roy, Caesar-Johnson Samantha J, Wang Zhining, Doane Ashley S, Khurana Ekta, Castro Mauro A A, Lazar Alexander J, Broom Bradley M, Weinstein John N, Akbani Rehan, Kumar Shwetha V, Raphael Benjamin J, Wong Christopher K, Stuart Joshua M, Safavi Rojin, Benz Christopher C, Johnson Benjamin K, Kyi Cindy, Shen Hui, Corces M Ryan, Chang Howard Y, Greenleaf William J
Abstract excerpt
To identify cancer-associated gene regulatory changes, we generated single-cell chromatin accessibility landscapes across eight tumor types as part of The Cancer Genome Atlas. Tumor chromatin accessibility is strongly influenced by copy number alterations that can be used to identify subclones, yet underlying cis-regulatory landscapes retain cancer type-specific features. Using organ-matched healthy tissues, we...
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