Article

Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria

2020-08-31

Abstract excerpt

<h4>Summary</h4> Inborn errors of human IFN-γ immunity underlie mycobacterial disease. We report a patient with mycobacterial disease due to an inherited deficiency of the transcription factor T-bet. This deficiency abolishes the expression of T-bet target genes, including IFNG , by altering chromatin accessibility and DNA methylation in CD4 + T cells. The patient has profoundly diminished counts of mycobacteri...

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Literature Corpus work: 1069e04b-4712-5ff5-8034-8af2c5d3a1c9
DOI: 10.1101/2020.08.31.274589

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