Article
High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency.
The Journal of experimental medicine - 2 Aug 2021
Yang Rui, Weisshaar Marc, Mele Federico, Benhsaien Ibtihal, Dorgham Karim, Han Jing, Croft Carys A, Notarbartolo Samuele, Rosain Jérémie, Bastard Paul, Puel Anne, Fleckenstein Bernhard, Glimcher Laurie H, Di Santo James P, Ma Cindy S, Gorochov Guy, Bousfiha Aziz, Abel Laurent, Tangye Stuart G, Casanova Jean-Laurent, Bustamante Jacinta, Sallusto Federica
Abstract excerpt
We have described a child suffering from Mendelian susceptibility to mycobacterial disease (MSMD) due to autosomal recessive, complete T-bet deficiency, which impairs IFN-γ production by innate and innate-like adaptive, but not mycobacterial-reactive purely adaptive, lymphocytes. Here, we explore the persistent upper airway inflammation (UAI) and blood eosinophilia of this patient. Unlike wild-type (WT) T-bet,...
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